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Updated: Aug 3, 2026
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Epizootic of group B Streptococcus agalactiae serotype V in DBA/2 mice
J G Geistfeld1, S H Weisbroth, E A Jansen
1Taconic, Germantown, New York 12526, USA.
Abstract:
Beta-hemolytic Streptococcus agalactiae serotype V was identified as the cause of an infection in laboratory mice. Principally, the organism induced fatal septicemia in DBA/2 breeding-age mice. The syndrome appeared to originate as an ascending pyelonephritis, which progressed to septicemia. Microscopic lesions were found in the heart, kidneys, spleen, and liver, and less commonly in the uterus, thoracic cavity, lymph nodes, and lungs. The epizootic was controlled by eradication of the breeding colonies, disinfection of the barrier, and autoclaving of all equipment. The new replacement colonies have remained free of the organism.
Insights
Streptococcus agalactiae serotype V caused fatal septicemia in laboratory mice, originating as a kidney infection. Control involved colony eradication and disinfection, successfully preventing recurrence in new colonies.
Area of Science:
- Veterinary Pathology
- Microbiology
- Infectious Diseases
Background:
- Beta-hemolytic Streptococcus agalactiae serotype V is an emerging pathogen.
- Serotype V infections can cause severe disease in animal models.
Purpose of the Study:
- To identify the causative agent of a fatal epizootic in laboratory mice.
- To characterize the clinical and pathological features of the infection.
- To determine effective control measures.
Main Methods:
- Bacteriological culture and identification of the causative agent.
- Histopathological examination of affected tissues.
- Implementation of eradication and disinfection protocols.
Main Results:
- Streptococcus agalactiae serotype V was identified as the cause of fatal septicemia.
- The infection originated as ascending pyelonephritis and progressed to systemic disease.
- Microscopic lesions were observed in multiple organs, including the heart, kidneys, spleen, and liver.
Conclusions:
- Streptococcus agalactiae serotype V poses a significant threat to laboratory mouse colonies.
- Eradication of infected colonies, thorough disinfection, and autoclaving of equipment are critical for disease control.
- Replacement colonies remained free of infection after implementing control measures.
