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Related Experiment Videos

Latex sensitivity in a macaque (Macaca mulatta).

J D Macy1, M J Huether, T A Beattie

  • 1Yale University School of Medicine, New Haven, Connecticut 06520-8016, USA.

Comparative Medicine
|April 2, 2002
PubMed
Summary
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A latex allergy caused allergic dermatitis in a rhesus macaque, presenting as pruritic skin lesions. Switching to vinyl gloves resolved symptoms, indicating latex as a key allergen in nonhuman primates.

Area of Science:

  • Veterinary Dermatology
  • Primate Immunology
  • Allergen Identification

Background:

  • An adult rhesus macaque presented with recurrent conjunctivitis and acute, pruritic dermatitis affecting multiple body regions.
  • Initial diagnostic tests, including skin scrapings, fungal cultures, and blood work, were largely unremarkable, except for eosinophilia.

Observation:

  • Skin biopsy revealed chronic, nonsuppurative eosinophilic dermatitis.
  • While patch testing for common allergens was negative, specific IgE testing strongly indicated a latex allergy.
  • A skin prick test confirmed significant inflammation upon exposure to latex.

Findings:

  • Latex allergy was identified as the cause of allergic dermatitis in this nonhuman primate.
  • Substitution of latex gloves with vinyl gloves led to a marked and sustained improvement in dermatitic symptoms.

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  • Histopathological examination post-treatment showed epidermal normalization, though mild perifolliculitis persisted.

    • Implications:

    • Latex can induce allergic dermatitis in nonhuman primates.
    • Latex allergy should be considered in the differential diagnosis of atopic dermatitis in nonhuman primates.
    • This case highlights the importance of environmental allergen identification in veterinary dermatology.