Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Unexpected drug-interaction].

Yutaka Tajima1

  • 1Clinical Laboratory, Saga Medical School Hospital, Saga 849-8501.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|April 3, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A Case of Aplastic or Twig-Like Middle Cerebral Artery Presenting with an Intracranial Hemorrhage Two Years after a Transient Ischemic Attack].

No shinkei geka. Neurological surgery·2016
Same author

Treatment of a ruptured aneurysm involved in a double origin of the posterior inferior cerebellar artery.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2015
Same author

HMGB1: A new marker for estimation of the postmortem interval.

Experimental and therapeutic medicine·2012
Same author

Coffee-induced Hypokalaemia.

Clinical medicine insights. Case reports·2011
Same author

[Anti-reticulin antibody].

Nihon rinsho. Japanese journal of clinical medicine·2010
Same author

Comparison of methods of detecting bacterial biofilm.

Clinical laboratory·2010

A patient with normal pressure hydrocephalus developed neuroleptic malignant syndrome-like symptoms after taking antidepressant and pravastatin. This case highlights the critical need for physicians to recognize potential unexpected drug interactions.

Area of Science:

  • Neurology
  • Clinical Pharmacology

Background:

  • Chronic normal pressure hydrocephalus (NPH) management presents complex challenges.
  • Patient presented with abulia and hypercholesterolemia, requiring pharmacotherapy.

Observation:

  • Administration of antidepressant and pravastatin initiated for patient's symptoms.
  • Development of neuroleptic malignant syndrome-like conditions observed post-medication.

Findings:

  • An unexpected drug interaction between antidepressant and pravastatin is suspected.
  • The adverse event mimicked neuroleptic malignant syndrome.

Implications:

  • Physicians must maintain high suspicion for rare drug interactions in clinical practice.
  • Emphasizes the importance of careful patient monitoring and rapid access to drug information systems.

Related Experiment Videos