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[Lhermitte's sign].

J M García-Moreno1, G Izquierdo

  • 1Unidad de Esclerosis Múltiple. Servicio de Neurología. Hospital Universitario Virgen Macarena. Sevilla. Spain.

Neurologia (Barcelona, Spain)
|April 3, 2002
PubMed
Summary

Lhermitte's sign, a neurological phenomenon often compared to electric shock, is frequently observed in multiple sclerosis. Its history, pathophysiology, and treatment are reviewed, highlighting its significance in neurological diagnosis.

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Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Medicine

Background:

  • Lhermitte's sign, a neurological symptom and sign, is characterized by an electric shock-like sensation radiating down the spine upon neck flexion.
  • Initially described following head and cervical spine trauma, its association with demyelinating conditions, particularly multiple sclerosis, was later recognized.

Discussion:

  • The historical evolution of Lhermitte's sign, from initial trauma-related descriptions to its specific attribution and pathophysiological interpretation by Jean Lhermitte.
  • The phenomenon's subjective nature, where patients often describe it with vivid analogies like electric currents, adds a unique dimension to its clinical understanding.

Key Insights:

  • Lhermitte's sign is a significant clinical finding, most commonly associated with multiple sclerosis, but also observed in various other neurological conditions.
  • While Jean Lhermitte proposed a pathophysiological mechanism involving the stretching of posterior cord white matter during neck flexion, its exact pathophysiology remains an area of ongoing research.

Outlook:

  • Further research into the precise pathophysiology of Lhermitte's sign may elucidate underlying mechanisms in demyelinating diseases.
  • Understanding the historical context and patient descriptions can enhance clinical recognition and diagnostic accuracy of this neurological phenomenon.

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