Related Experiment Videos
Cyclophilin a plays distinct roles in human immunodeficiency virus type 1 entry and postentry events, as revealed by
Andrew C S Saphire1, Michael D Bobardt, Philippe A Gallay
1Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.
Journal of Virology
|April 5, 2002
Abstract:
Cyclophilin A (CypA) is necessary for effective human immunodeficiency virus type 1 (HIV-1) replication. However, the functions of CypA and the precise steps at which CypA acts in the HIV-1 life cycle remain to be determined. By using a methodology that bypasses the need for attachment factors-spinoculation-we present evidence that CypA participates in both entry and postentry events.