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Receptors for NGF and GDNF are highly expressed in human peripheral nerve neuroma
Christoph Harpf1, Jörg Dabernig, Christian Humpel
1University Clinic for Plastic and Reconstructive Surgery, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. christoph.harpf@uibk.ac.at
Abstract:
Immunhistochemistry of 10 traumatic human peripheral nerve neuromas and 5 normal digital nerves revealed a high immunoreactivity for the nerve growth factor (NGF) receptors p75 and trkA and the glial cell line-derived neurotrophic factor (GDNF) receptor GFRalpha-1. Semiquantitative image analysis showed a significantly increased trkA immunoreactivity in the neuroma group. The presence of the receptors may provide a way to influence therapy of peripheral nerve neuroma by administration of neurotrophins or other substances with binding sites similar to those of a neurotrophic factor.