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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

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[Not Available].

MMW Fortschritte der Medizin·2016
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Chronic abdominal pain aggravated by eating: diagnosis by video capsule endoscopy.

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Related Experiment Video

Updated: Jul 12, 2026

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

[Nonalcoholic fatty liver].

H Dancygier1

  • 1Medizinischen Klinik II, Klinikum Offenbach.

Versicherungsmedizin
|April 6, 2002
PubMed
Summary
This summary is machine-generated.

Nonalcoholic fatty liver disease (NAFLD) is linked to obesity and diabetes, potentially progressing to cirrhosis. Currently, effective treatments are unavailable, highlighting a critical need for therapeutic advancements.

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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
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Area of Science:

  • Hepatology
  • Gastroenterology
  • Internal Medicine

Context:

  • Nonalcoholic fatty liver disease (NAFLD) is frequently associated with metabolic conditions like obesity, type II Diabetes mellitus, and hyperlipidemia.
  • It can also be linked to chronic viral hepatitis C, presenting a complex etiological profile.
  • The disease spectrum ranges from simple fatty liver to steatohepatitis, fibrosis, and potentially cirrhosis.

Purpose:

  • To summarize the key aspects of Nonalcoholic Fatty Liver Disease (NAFLD).
  • To highlight the association of NAFLD with metabolic disorders and its progression.
  • To underscore the current limitations in therapeutic options for NAFLD.

Summary:

  • NAFLD encompasses a range of liver conditions, from fatty infiltration to cirrhosis, often asymptomatic with mild aminotransferase elevation.
  • Accurate assessment of inflammation and fibrosis requires liver biopsy, as clinical signs are often minimal.
  • A significant portion of cryptogenic cirrhosis cases may be attributed to nonalcoholic steatohepatitis, indicating its progressive potential.

Impact:

  • NAFLD represents a growing public health concern due to its association with metabolic syndrome.
  • Understanding the progression of NAFLD is crucial for identifying at-risk individuals.
  • The lack of proven therapeutic modalities emphasizes the urgent need for research and development in NAFLD treatment.