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Related Experiment Video

Updated: Jul 9, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

[Whipple disease--a rare systemic disease].

H Dancygier¹, W Scharnke

¹Medizinische Klinik II, Klinikum Offenbach, Akademisches Lehrkrankenhaus, J. W. Goethe-Universität, Frankfurt am Main. hdancygier@t-online.de

|November 9, 2002

Summary

This summary is machine-generated.

Whipple's disease is a rare bacterial infection caused by Tropheryma whipplei. Long-term antibiotic treatment is crucial to prevent relapses of this potentially fatal systemic illness.

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Area of Science:

Infectious Diseases
Microbiology
Gastroenterology

Context:

Whipple's disease is a rare, systemic infectious disease caused by Tropheryma whipplei.
It primarily affects middle-aged men and can lead to severe gastrointestinal and systemic symptoms.
Central nervous system involvement is common, often presenting asymptomatically.

Purpose:

To summarize the key aspects of Whipple's disease, including its causative agent, clinical manifestations, diagnostic methods, and treatment protocols.
To emphasize the importance of early diagnosis and appropriate management to prevent disease recurrence.

Summary:

Tropheryma whipplei, a Gram-positive bacterium, is the causative agent of Whipple's disease.
Diagnosis relies on identifying the bacteria via microscopy and PCR in affected tissues and fluids.
Typical findings include PAS-positive macrophages in duodenal biopsies, though PCR confirmation is now standard.
Clinical features encompass weight loss, diarrhea, abdominal pain, arthralgias, and potential CNS involvement.

Impact:

Highlights the necessity of long-term antibiotic therapy, particularly agents crossing the blood-brain barrier, to ensure treatment efficacy.
Stresses the importance of confirming the absence of Tropheryma whipplei in both duodenal tissue and cerebrospinal fluid before discontinuing treatment to avoid relapses.