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Gelastic seizures and low-grade hypothalamic astrocytoma: a case report
Giangennaro Coppola1, Diego Spagnoli, Nicola Sciscio
1Department of Pediatrics, Clinic of Child and Adolescent Neuropsychiatry, Second University of Naples, Via Pansini 5, 80131 Naples, Italy. giangennaro.coppola@unina2.it
Abstract:
The typical, well recognized childhood epilepsy syndrome caused by hypothalamic hamartoma is characterized by early-onset, stereotyped attacks of uncontrollable laughter, frequent refractory seizures with progressive cognitive deterioration and severe behavioral problems. Here, we report a 17-year-old patient with gelastic phenomenon started in the neonatal period, later on associated with drug resistant polymorphic seizures, intellectual deficit and behavioral disorders, who improved by partial resection of an expected hypothalamic hamartoma that, in turn, resulted to be a hypothalamic low-grade astrocytoma.
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