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[Exo- and endocrine testicular function in the aging man]
Fortschritte Der Medizin
|November 6, 1975
Summary
In aging males over 60, follicle-stimulating hormone (FSH) levels stay stable, but luteinizing hormone (LH) increases. Testosterone declines, impacting tissue sensitivity and sperm production.
Area of Science:
- Endocrinology
- Reproductive Biology
- Aging Research
Background:
- Hormonal changes are common in aging males.
- Understanding these changes is crucial for male reproductive health.
- Previous research has indicated shifts in hormone levels with age.
Purpose of the Study:
- To investigate the hormonal profile in males over 60.
- To assess changes in testosterone levels and binding.
- To evaluate the impact of these changes on androgen-dependent tissues and spermatogenesis.
Main Methods:
- Analysis of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) excretion.
- Measurement of plasma total and free testosterone.
- Assessment of testosterone binding proteins and metabolic clearance rate.
- Evaluation of androgen-dependent target tissue sensitivity.
- Spermatogenesis assessment.
Main Results:
- FSH excretion remained stable in males over 60.
- LH secretion significantly increased in this age group.
- Plasma testosterone and its biologically active fraction decreased.
- Percentage of protein-bound, biologically inactive testosterone increased.
- Androgen-dependent target tissues showed reduced sensitivity to testosterone.
- Metabolic clearance rate of testosterone decreased.
- Spermatogenesis appeared to remain intact, though further research is needed.
Conclusions:
- Aging in males over 60 is characterized by increased LH secretion and decreased testosterone levels.
- Reduced testosterone bioavailability and target tissue sensitivity occur with age.
- While spermatogenesis may be preserved, comprehensive research is lacking.