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[Blue-red macules and pseudoatrophic macules in neurofibromatosis 1]
J Zeller1, J Wechsler, J Revuz
1Service de Dermatologie, Hôpital Henri-Mondor (AP-HP), Université Paris XII, 94010 Créteil.
Introduction:
Blue-red macules are exception during neurofibromatosis 1. Between October 1988 and March 2000 in our cohort of patients, we systematically looked for these lesions.
Patients And Methods:
Presence and number of blue-red macules were evaluated. Biopsies and photographs were proposed to patients.
Results:
Forty-four patients out of 583 (39 y; range: 20-66 y) (7.5 p. 100; CI 95 p. 100: 5.5-9.8 p. 100) had blue-red macules mainly on the trunk. Histologically, blue-red macules corresponded to neurofibromatous tissue infiltrating capillary blood vessels and venules.
Conclusion:
Blue-red macules are a peculiar type of neurofibroma and can therefore be considered as a criterion for the diagnosis of neurofibromatosis 1.