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Updated: Jul 16, 2026
07:06
Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
[Study on toxicity of P-Dichlorobenzene]
1Institute of Environmental Health Monitoring, Chinese Academy of Preventive Medicine, Beijing 100021, China.
Wei Sheng Yan Jiu = Journal of Hygiene Research
|April 10, 2002
Summary
Para-dichlorobenzene (P-DCB) exhibits low toxicity, with no significant accumulation or sensitization. While mild skin irritation occurred, no organ damage or genotoxicity was detected in toxicity studies.
Area of Science:
- Toxicology
- Environmental Health
- Chemical Safety
Context:
- Assessing the toxicological profile of para-dichlorobenzene (P-DCB)
- Evaluating potential health risks associated with P-DCB exposure
- Understanding the environmental fate and biological interactions of P-DCB
Purpose:
- To comprehensively evaluate the toxicity of P-DCB
- To determine P-DCB's potential for accumulation, irritation, sensitization, and organ damage
- To assess the genotoxic potential of P-DCB
Summary:
- P-DCB demonstrated low toxicity, with no significant bioaccumulation (K > 5).
- No eye irritation or skin sensitization was observed; however, mild skin irritation was noted.
- Sub-acute inhalation exposure did not result in liver or kidney dysfunction. Genotoxicity tests in S. typhimurium and Chinese hamster lung fibroblast cells showed no mutagenic or clastogenic potential.
Impact:
- Provides crucial data for regulatory risk assessments of P-DCB
- Informs safe handling practices and occupational exposure limits for P-DCB
- Contributes to the understanding of P-DCB's environmental and health safety profile
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