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Primary cutaneous diffuse large B-cell lymphoma: a clinicopathologic study of 15 cases
Thomas A Hembury1, Benita Lee, Randy D Gascoyne
1Department of Clinical Pathology, Cleveland Clinic Foundation, OH 44195, USA.
American Journal of Clinical Pathology
|April 10, 2002
Summary
Primary cutaneous diffuse large B-cell lymphoma (DLBCL) is rare, typically affecting older men. Tumors on the lower extremity show a higher recurrence rate than those elsewhere.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Primary cutaneous diffuse large B-cell lymphoma (DLBCL) is an uncommon non-Hodgkin lymphoma.
- The unique characteristics of DLBCL on the lower extremity are not well-defined.
Purpose of the Study:
- To analyze clinical and immunohistochemical features of primary cutaneous DLBCL.
- To compare outcomes for DLBCL on the lower extremity versus other sites.
Main Methods:
- Retrospective analysis of 15 primary cutaneous DLBCL cases.
- Immunohistochemistry for CD3, CD5, CD10, CD20, bcl-2, bcl-6, and p53.
- PCR for t(14;18) translocation.
Main Results:
- The study included 13 men and 2 women (median age, 64 years).
- Thirteen tumors were centroblastic, and 2 were immunoblastic.
- 50% of lower extremity DLBCL cases recurred, with 1 death. Non-lower extremity cases had an 18% recurrence rate and no deaths.
Conclusions:
- Primary cutaneous DLBCL predominantly affects elderly males.
- Recurrences are frequent, but disease-related mortality is low.
- Lower extremity DLBCL may have a distinct, more aggressive behavior.