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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Sesterterpenoids
Lishu Wang1, Bin Yang, Xiu-Ping Lin
1Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Natural Product Reports
|February 7, 2013
Summary
This review summarizes sesterterpenoids, detailing their biological activities, natural sources, and origins. It includes key total syntheses that revised compound structures and stereochemistry.
Area of Science:
- Natural Product Chemistry
- Organic Chemistry
- Medicinal Chemistry
Background:
- Sesterterpenoids are a class of terpenoids with diverse biological activities.
- Understanding their chemistry and origin is crucial for drug discovery.
- Literature on sesterterpenoids is extensive but fragmented.
Purpose of the Study:
- To consolidate the existing literature on sesterterpenoids.
- To highlight their biological activities, source organisms, and geographical origins.
- To include significant total syntheses impacting structural and stereochemical understanding.
Main Methods:
- Comprehensive literature search across scientific databases.
- Inclusion of studies detailing sesterterpenoid isolation and characterization.
- Focus on total synthesis reports that led to structural or stereochemical revisions.
Main Results:
- Compilation of data on numerous sesterterpenoids from various natural sources.
- Summary of reported biological activities, including antimicrobial, cytotoxic, and anti-inflammatory effects.
- Inclusion of 166 references covering recent advancements.
Conclusions:
- Sesterterpenoids represent a rich area of natural product research with significant therapeutic potential.
- Total synthesis plays a vital role in confirming and refining the structures of these complex molecules.
- This review serves as a valuable resource for researchers in natural product chemistry and drug discovery.
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