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Sonodynamic therapy inhibits angiogenesis and tumor growth in a xenograft mouse model
Zhongxiuzi Gao1, Jinhua Zheng, Bin Yang
1Laboratory of Sono- and Photo-theranostic Technologies, Harbin Institute of Technology, Harbin 150080, China.
Abstract:
Studies of sonodynamic therapy (SDT) have mainly focused on its direct cytotoxic effect on tumor cells. Its effects on the tumor microenvironment, especially angiogenesis, remain unknown. In this study, we found that SDT significantly inhibited endothelial cell proliferation, migration, invasion, and tube formation. Furthermore, in a tumor xenograft mouse model, SDT was found to remarkably suppress tumor growth, intratumoral vascularity, and expression of vascular endothelial growth factor in tumor cells. An ultrastructural study showed damage and disruption of tumor microvasculature after STD. Our results indicate that SDT inhibits neovascularization in tumor, which is partially responsible for the anti-tumor effect of SDT.
Insights
Sonodynamic therapy (SDT) inhibits tumor growth by suppressing new blood vessel formation (angiogenesis). This study reveals SDT
Area of Science:
- Oncology
- Biomedical Engineering
- Cancer Research
Background:
- Sonodynamic therapy (SDT) primarily studied for direct tumor cell cytotoxicity.
- The impact of SDT on the tumor microenvironment, particularly angiogenesis, is largely unexplored.
Purpose of the Study:
- To investigate the effects of SDT on angiogenesis and its contribution to anti-tumor activity.
Main Methods:
- In vitro assays assessing endothelial cell proliferation, migration, invasion, and tube formation.
- In vivo studies using a tumor xenograft mouse model.
- Ultrastructural analysis of tumor microvasculature.
Main Results:
- SDT significantly inhibited endothelial cell functions crucial for blood vessel development.
- Tumor growth, intratumoral vascularity, and VEGF expression were markedly reduced by SDT in vivo.
- Ultrastructural examination revealed damage to tumor microvasculature post-SDT.
Conclusions:
- SDT effectively inhibits tumor-associated neovascularization.
- Suppression of angiogenesis is a key mechanism underlying the anti-tumor efficacy of SDT.
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