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Subgingival microbial profiles in refractory periodontal disease
Sigmund S Socransky1, Claire Smith, Anne D Haffajee
1Department of Periodontology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA.
Journal of Clinical Periodontology
|April 10, 2002
Summary
Four distinct subgingival microbial profiles were identified in refractory periodontitis cases. These "refractory microbial profiles" were also found in individuals without refractory disease, suggesting early microbial indicators.
Area of Science:
- Microbiology
- Periodontology
- Oral Health
Background:
- Refractory periodontitis presents a significant clinical challenge.
- Understanding its microbial etiology is crucial for effective management.
Purpose of the Study:
- To characterize subgingival microbial profiles in refractory periodontitis.
- To compare these profiles with those in healthy, well-maintained elder, and untreated periodontitis subjects.
Main Methods:
- Subgingival plaque samples from 36 refractory periodontitis subjects were analyzed using checkerboard DNA-DNA hybridization.
- Cluster analysis identified distinct microbial profiles.
- Profiles were compared across healthy, elder, and untreated periodontitis groups.
Main Results:
- Four distinct microbial profiles were identified among refractory periodontitis subjects.
- Three of these profiles were also detected in healthy, elder, and untreated periodontitis groups.
- A unique profile dominated by Streptococcus species was not found in non-refractory subjects.
Conclusions:
- Subgingival microbial profiling can identify distinct patterns associated with refractory periodontitis.
- "Refractory microbial profiles" may precede the clinical manifestation of refractory disease.
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