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Interleukin-2 in the pathogenesis of perinatal white matter damage
H Kadhim1, B Tabarki, C De Prez
1Laboratoire de Neurologie du Développement, Université Catholique de Louvain, Brussels, Belgium. Hazim.Kadhim@nepe.ucl.ac.be
Neurology
|April 10, 2002
Abstract:
Proinflammatory cytokines were reported to be implicated in the pathogenesis of perinatal white matter lesions. The authors document for the first time the in situ detection of interleukin-2 and interleukin-2 receptor (IL-2R) in these human white matter lesions. These results suggest that interleukin-2, reported to be toxic to oligodendrocytes and myelin, could play a role in the molecular cascade leading to white matter damage in periventricular leukomalacia.