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Therapeutic hypothermia in children: Which indications remain in 2018?

F Thabet1, B Tabarki2

  • 1Division of Pediatric Critical Care.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|July 7, 2019
PubMed

Insights

Therapeutic hypothermia shows promise for pediatric acute brain injury, potentially reducing seizures and intracranial pressure. Further research is needed to confirm benefits in children beyond the neonatal period.

Area of Science:

  • Neuroscience
  • Pediatric Critical Care
  • Neurology

Background:

  • Experimental studies suggest therapeutic hypothermia benefits acute brain injury.
  • Potential benefits include reduced seizure incidence and intracranial pressure.
  • Translating these findings to pediatric patients presents challenges.

Purpose of the Study:

  • To review current indications for therapeutic hypothermia in pediatric acute brain injury (beyond neonates).
  • To analyze neurologic outcomes and mortality data from existing studies.
  • To discuss the benefits of therapeutic hypothermia in this population.

Main Methods:

  • Narrative review of published studies.
  • Analysis of neurologic outcome and mortality data.
  • Focus on pediatric patients (excluding neonatal period).

Main Results:

  • Therapeutic hypothermia has shown positive outcomes in experimental settings.
  • Evidence for pediatric application in conditions like cardiac arrest and traumatic brain injury is being evaluated.
  • Data on neurologic outcomes and mortality in pediatric patients is synthesized.

Conclusions:

  • Therapeutic hypothermia holds potential for pediatric acute brain injury.
  • Further investigation is required to establish definitive indications and benefits.
  • Optimizing treatment protocols for pediatric populations is crucial.

Keywords:
Brain injuryCardiac arrestHypothermiaSeizures

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