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Updated: Oct 1, 2026

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
Published on: April 11, 2019
Effect of a Single Nighttime Dose of Oxazepam on Seizure Duration in Electroconvulsive Therapy
Anders C. Olesen1, Anette Lolk, Peder Christensen
1Department of Psychiatry, Middelfart Hospital, Middelfart, Denmark.
Abstract:
In a double-blind crossover study, 12 depressed inpatients receiving bilateral electroconvulsive therapy (ECT) were given 22.5 mg oxazepam or placebo (identical tablets, randomized order) the night before treatment. Seizure duration was measured using the cuff method and a total of 20 pairs of measurements were made. Mean duration after oxazepam administration was 0.9 s longer than after placebo; this difference was not statistically significant. The relevant lower one-sided 95% confidence limit was -4.1 s. Single administration of oxazepam, 22.5 mg, has little average effect on seizure duration in ECT.
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