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Updated: Aug 10, 2026
12:51
Murine Model of Hindlimb Ischemia
Published on: January 21, 2009
The ArtAssist Device in chronic lower limb ischemia. A pilot study
G Louridas1, R Saadia, J Spelay
1Section of Vascular Surgery, the Department of Surgery, University of Manitoba, St. Boniface Hospital and Health Sciences Centre, Winnipeg, Manitoba, Canada.
Summary
The ArtAssist Device shows promise in improving pedal blood flow and potentially reducing amputation rates in patients with critical limb ischemia. Further validation in larger studies is recommended.
Area of Science:
- Vascular Surgery
- Cardiovascular Medicine
- Regenerative Medicine
Background:
- Chronic critical limb ischemia (CLI) carries a poor prognosis, especially after failed bypass or in non-reconstructable distal disease.
- Patients with CLI often face high amputation rates and limited treatment options.
Purpose of the Study:
- To evaluate the efficacy of the ArtAssist Device in improving pedal blood flow.
- To assess the impact of the ArtAssist Device on amputation rates in patients with CLI.
Main Methods:
- A prospective pilot study involving 33 legs across 25 patients with CLI.
- Patients presented with rest pain or tissue loss; some had prior bypass surgery.
- Measurements included pedal blood flow (toe pressures) and amputation outcomes at a 3-month follow-up.
Main Results:
- The ArtAssist Device demonstrated a significant improvement in toe pressures (p=0.03).
- Overall, 58% of legs were saved, with an amputation rate of 42%. Excluding patients with chronic renal failure, the amputation rate decreased to 13.6%.
- Improvements were observed in rest pain (40%) and foot ulcer healing (26%) for patients using the device.
Conclusions:
- The ArtAssist Device shows encouraging results for managing CLI, improving hemodynamic parameters and limb salvage.
- The findings warrant further investigation in larger, randomized controlled trials to confirm efficacy and safety.
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