The effects of immunization against cholecystokinin fragment 30-33 in the behavior of white rats
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Published on: May 2, 2018
R A Danilova1, O I Rud'ko, T M Korotkova
1M. V. Lomonosov Moscow State University, Russia.
Abstract:
Active immunization of white rats with cholecystokinin-4 covalently linked to the antigen carrier BSA evoked long-lasting changes in the rats' behavior, which were in the opposite direction to the anxiogenic effects of cholecystokinin-4 itself, showing that immunization had anxiolytic effects. Immunoenzyme analysis demonstrated the presence of antibodies to cholecystokinin-4 in the serum of immunized rats. These data are interesting from the point of view of correcting pathological anxiety and fear states by inverse immunoregulation.
