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High free energy of lipid/protein interaction in biological membranes
1GSF-National Research Center for Environment and Health, Institute for Biochemical Plant Pathology, D-85764 Neuherberg, Germany. sandermann@gsf.de
FEBS Letters
|April 12, 2002
Abstract:
The free energy of lipid/protein interaction in biological membranes is still unknown although extensive partitioning and modelling studies have revealed many partial energetic increments. Multiple site binding kinetics are now applied to four well-studied functional membrane proteins, and mean free energy values (+/-S.D.) of -4.23+/-0.49 kcal/mol for single lipid binding sites and of -89.7+/-35.4 kcal/mol for complete lipid substitution are obtained. These high free energy values point to an important bioenergetic role of lipid/protein interaction in membrane functions.