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Updated: Dec 17, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
Published on: February 20, 2018
Mechanisms of cross-talk between G-protein-coupled receptors
Yolande Cordeaux1, Stephen J Hill
1Institute of Cell Signalling and School of Biomedical Sciences, Queens Medical Centre, Nottingham, UK. yolande.cordeaux@nottingham.ac.uk
Abstract:
There is increasing evidence to suggest that 'cross-talk' occurs between G-protein-coupled receptors and their intracellular second messenger pathways. Cross-talk between different pathways may occur at the level of receptors, G-proteins, effectors or second messengers and may serve to fine-tune cell signalling. There is a growing body of evidence to suggest that cellular compartmentalization may play a crucial role in regulating these cross-talk interactions. Understanding the mechanisms of cross-talk may therefore be the key to the design and application of future therapeutics and the development of drug specificity.
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