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[Role of polypeptide growth factors in the regulation of epidermal keratinocyte proliferation]

V K Gusak, R G Vasil'ev, D A Zubov

    Tsitologiia I Genetika
    |April 12, 2002
    PubMed

    Insights

    This review summarizes growth factors and their receptors, crucial for cell communication. It examines regulatory roles of specific growth factors in skin keratinocytes, both in living organisms and in lab settings.

    Area of Science:

    • Cell biology
    • Molecular biology
    • Biochemistry

    Context:

    • Intercellular interactions rely on growth factors, cytokines, adhesion molecules, and extracellular matrix.
    • Cellular communication is fundamental to tissue development and homeostasis.

    Purpose:

    • To review the structure and function of growth factors and their receptors.
    • To explore the regulatory roles of specific growth factors in epidermis keratinocytes.

    Summary:

    • The review consolidates information on growth factor and receptor mechanisms.
    • It details the functions of Epidermal Growth Factor (EGF), Transforming Growth Factor alpha (TGFα), Transforming Growth Factor beta (TGFβ), Fibroblast Growth Factor (FGF), Keratinocyte Growth Factor (KGF), Amphiregulin (AR), and Hepatocyte Growth Factor (HGF).
    • Regulatory functions are exemplified in epidermis keratinocytes, considering both in vivo and in vitro models.

    Impact:

    • Provides a comprehensive overview of growth factor signaling in keratinocytes.
    • Highlights the importance of these molecules in cellular processes.
    • Serves as a resource for researchers studying cell communication and skin biology.

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