Related Experiment Videos
Application of high-throughput, molecular-targeted screening to anticancer drug discovery
Robert H Shoemaker1, Dominic A Scudiero, Giovanni Melillo
1Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick, Maryland 21702-1201, USA. shoemaker@dtpax2.ncifcrf.gov
Abstract:
Increasing insight into the genetics and molecular biology of cancer has resulted in the identification of an increasing number of potential molecular targets for anti-cancer drug discovery and development. These targets can be approached through exploitation of emerging structural biology, "rational" drug design, screening of chemical libraries, or a combination of these methods. In this article we discuss the application of high-throughput screening to anti-cancer drug discovery, with special reference to approaches used at the U.S. National Cancer Institute.
Insights
Advances in cancer genetics reveal new molecular targets for drug discovery. High-throughput screening methods are crucial for identifying novel anti-cancer therapeutics, as exemplified by U.S. National Cancer Institute approaches.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Cancer genetics and molecular biology research continually identifies novel molecular targets.
- These targets are essential for developing new anti-cancer drugs.
- Structural biology and rational drug design are key approaches.
Purpose of the Study:
- To discuss the application of high-throughput screening (HTS) in anti-cancer drug discovery.
- To highlight HTS approaches utilized by the U.S. National Cancer Institute (NCI).
Main Methods:
- Utilizing structural biology insights.
- Employing rational drug design principles.
- Screening extensive chemical libraries.
- Applying high-throughput screening (HTS) methodologies.
Main Results:
- Identification of numerous potential molecular targets for anti-cancer drug development.
- Demonstration of HTS as a viable strategy for discovering anti-cancer agents.
- Showcasing specific HTS approaches used at the NCI.
Conclusions:
- High-throughput screening is a powerful tool in modern anti-cancer drug discovery.
- Integration of various methods, including HTS, accelerates the development of novel therapeutics.
- NCI's experience provides valuable insights into effective HTS strategies for oncology drug development.