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Related Experiment Videos

Sildenafil increases ocular perfusion.

G Paris1, W E Sponsel, S S Sandoval

  • 1South Texas Ocular Imaging Center, Ophthalmology Department, University of Texas Health Science Center at San Antonio, USA.

International Ophthalmology
|April 12, 2002
PubMed
Summary
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Sildenafil increased ocular perfusion and contrast sensitivity in healthy adults. This suggests sildenafil may positively impact choroidal vasculature and visual function, offering potential clinical benefits.

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Physiology

Background:

  • The human choroid, crucial for outer retinal metabolism, functions as erectile tissue.
  • Understanding sildenafil's ocular effects is important due to its mechanism of action.

Purpose of the Study:

  • To investigate if sildenafil administration alters ocular perfusion and visual system responses.
  • To determine the impact of sildenafil on choroidal blood flow and contrast sensitivity.

Main Methods:

  • 12 healthy adults received a 50 mg oral dose of sildenafil.
  • Measurements included pulsatile ocular blood flow (POBF), intraocular pressure (IOP), retinal flowmetry (HRF), contrast sensitivity (CS), and visual field perimetry (FDT).
  • Ocular and blood pressure parameters were assessed before and 2 hours after sildenafil intake.

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Main Results:

  • POBF increased by 29.4% and CS by 33.6% post-sildenafil.
  • No subjects experienced decreased POBF or CS.
  • HRF flow values showed a modest increase, while FDT perimetry and IOP remained stable.

Conclusions:

  • Sildenafil significantly enhances ocular perfusion and contrast sensitivity.
  • The drug appears to induce intrinsic changes in choroidal vasculature.
  • These findings suggest potential clinical utility for sildenafil in improving visual function.