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François Grosclaude1, Marie Françoise Mahé, Jean Claude Mercier

  • 1Laboratoire de Génétique biochemique et Laboratoire de recherches sur les protéines, I.N.R.A., Jouy-en-Josas, France

FEBS Letters
|November 18, 1970
PubMed
Summary

The A variant of bovine alpha(s1) casein lacks 13 amino acids at the N-terminus compared to B and C variants. This structural difference impacts the bovine milk protein

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Dairy Science

Background:

  • Bovine alpha(s1) casein is a major milk protein.
  • Genetic variants (A, B, C) of alpha(s1) casein exist.
  • These variants differ in their amino acid sequences.

Purpose of the Study:

  • To characterize the structural differences between bovine alpha(s1) casein variants.
  • To identify the specific region absent in the A variant.

Main Methods:

  • Amino acid sequence analysis.
  • Peptide mapping (implied).

Main Results:

  • The A variant of bovine alpha(s1) casein is missing a 13-amino acid segment.
  • This deletion occurs at the NH(2)-terminal, positions 14-26.
  • The B and C variants contain this segment.

Conclusions:

  • Variant A exhibits a distinct N-terminal truncation.
  • This structural variation has implications for casein function and properties.