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Related Experiment Videos

Isokinetic muscle function in COPD.

Charles Haccoun1, Argyrios A Smountas, William J Gibbons

  • 1Montreal Children's Hospital-McGill University Health Centre, Montreal, PQ, Canada.

Chest
|April 12, 2002
PubMed
Summary
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A 20-second isokinetic test effectively predicts maximal exercise capacity in patients with chronic obstructive pulmonary disease (COPD), combining lung function (FEV1) and leg muscle function. This offers a practical alternative to longer tests for assessing exercise limitation in COPD.

Area of Science:

  • Pulmonary Medicine
  • Exercise Physiology
  • Rehabilitation Science

Background:

  • Exercise limitation in COPD is multifactorial, involving impaired lung function and reduced skeletal muscle function.
  • Previous prediction models for exercise capacity used FEV1 and a 30-second isokinetic sprint test.
  • The 30-second test may not be suitable for patients with advanced COPD.

Purpose of the Study:

  • To investigate the relationship between maximal exercise capacity (Wmax), FEV1, and shorter-duration isokinetic leg muscle function tests in COPD patients and healthy controls.
  • To determine if isokinetic work achieved at intervals less than 30 seconds can predict Wmax.
  • To assess the utility of a shorter isokinetic test for evaluating leg function in COPD.

Main Methods:

  • Twenty-seven COPD patients and 29 healthy controls underwent spirometry, progressive cycle ergometry, and 30-second isokinetic cycling.

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  • Measurements included FEV1, Wmax, and isokinetic work at 10, 15, 20, 25, and 30 seconds (W10-W30).
  • Statistical analysis involved correlation and two-factor modeling to predict Wmax.

    • Main Results:

    • COPD patients had significantly lower FEV1 and Wmax compared to controls.
    • Wmax correlated significantly with FEV1 and all isokinetic work measures (W10-W30) in both groups.
    • Combining FEV1 and isokinetic work (e.g., W20) in a two-factor model yielded high coefficients of determination (r² ≈ 0.58 for COPD, ≈ 0.71 for controls).

    Conclusions:

    • Both ventilatory function and leg muscle function are critical determinants of exercise limitation in COPD.
    • A 20-second isokinetic test is a viable and practical tool for assessing leg muscle function and predicting exercise capacity in COPD patients.
    • This finding supports the use of shorter, well-tolerated tests in clinical practice for COPD management.