Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute intoxication with sodium valproate.

D W Chadwick, W J Cumming, I Livingstone

    Annals of Neurology
    |December 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Two patients experienced toxic encephalopathy from sodium valproate, showing confusion and worsening seizures. Reducing the sodium valproate dose resolved these toxic symptoms.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The District General Hospital as a Resource for the Provision of Neurological Services.

    Journal of the Royal College of Physicians of London·2019
    Same author

    Orbital cellulitis in Scotland: current incidence, aetiology, management and outcomes.

    The British journal of ophthalmology·2014
    Same author

    New insight into non-healing corneal ulcers: iatrogenic crystals.

    Eye (London, England)·2013
    Same author

    Sensitivity and specificity of the step VEP in suspected functional visual acuity loss.

    Documenta ophthalmologica. Advances in ophthalmology·2012
    Same author

    Late-onset temporal lobe epilepsy with unilateral mesial temporal sclerosis and cognitive decline: a diagnostic dilemma.

    Seizure·2008
    Same author

    A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial.

    Health technology assessment (Winchester, England)·2007
    Same journal

    Five Issues of Artificial Intelligence in Science: Sailing the Ship of Theseus.

    Annals of neurology·2026
    Same journal

    Reply to "Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm".

    Annals of neurology·2026
    Same journal

    Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm.

    Annals of neurology·2026
    Same journal

    Imaging of Neurovascular Compression in Thoracic Outlet Syndrome.

    Annals of neurology·2026
    Same journal

    Reply to "Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease".

    Annals of neurology·2026
    Same journal

    Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease.

    Annals of neurology·2026
    See all related articles

    Area of Science:

    • Neurology
    • Clinical Toxicology

    Background:

    • Sodium valproate is a widely used antiepileptic drug.
    • Understanding its toxic effects is crucial for patient safety.

    Observation:

    • Two epileptic patients on sodium valproate monotherapy presented with acute toxic encephalopathy.
    • Symptoms included altered behavior, confusion, and deteriorated seizure control.

    Findings:

    • Both patients had elevated serum valproate levels (>100 microgram/ml).
    • Dose reduction led to symptom resolution and decreased serum valproate concentrations.

    Implications:

    • This case highlights the potential for sodium valproate toxicity even in monotherapy.
    • Therapeutic drug monitoring is important to prevent adverse events in epilepsy management.