Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The apolipoprotein E gene, attention, and brain function.

Raja Parasuraman1, Pamela M Greenwood, Trey Sunderland

  • 1Cognitive Science Laboratory, Catholic University of America, Washington, DC 20064, USA. parasuraman@cua.edu

Neuropsychology
|April 13, 2002
PubMed
Summary

The apolipoprotein E (ApoE) epsilon4 allele is linked to visuospatial attention deficits, similar to Alzheimer's disease (AD) symptoms, even in healthy individuals. This highlights ApoE genetics

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preferred Sources of Information, Knowledge, and Acceptance of Automated Vehicle Systems: Effects of Gender and Age.

Frontiers in psychology·2022
Same author

Editorial: Cognitive and Brain Aging: Interventions to Promote Well-Being in Old Age.

Frontiers in aging neuroscience·2020
Same author

Editorial: Cognitive and Brain Aging: Interventions to Promote Well-Being in Old Age.

Frontiers in aging neuroscience·2019
Same author

Comparing the Relative Strengths of EEG and Low-Cost Physiological Devices in Modeling Attention Allocation in Semiautonomous Vehicles.

Frontiers in human neuroscience·2019
Same author

A functional promoter variant of the human formimidoyltransferase cyclodeaminase (FTCD) gene is associated with working memory performance in young but not older adults.

Neuropsychology·2018
Same author

Individual differences in learning correlate with modulation of brain activity induced by transcranial direct current stimulation.

PloS one·2018

Area of Science:

  • Neuroscience
  • Genetics
  • Cognitive Psychology

Background:

  • The apolipoprotein E (ApoE) epsilon4 allele is a significant genetic risk factor for Alzheimer's disease (AD).
  • Aging and AD are associated with changes in visuospatial attention and working memory.
  • Understanding preclinical AD is crucial for early detection and intervention.

Purpose of the Study:

  • To investigate the association between the ApoE epsilon4 allele and visuospatial attention deficits.
  • To compare attention and working memory in ApoE epsilon4 carriers without dementia to AD patients.
  • To explore potential molecular mechanisms linking ApoE genotype to attention and brain function.

Main Methods:

  • Cognitive assessments focusing on visuospatial attention and working memory.

Related Experiment Videos

  • Genotyping for apolipoprotein E (ApoE) polymorphism.
  • Comparison of cognitive performance between healthy adults with and without the ApoE epsilon4 allele, and with AD patients.

    • Main Results:

    • Healthy middle-aged adults carrying the ApoE epsilon4 allele exhibited spatial attention and working memory deficits.
    • These deficits were qualitatively similar to those observed in clinically diagnosed Alzheimer's disease patients.
    • Findings support a direct link between ApoE genotype and specific visuospatial attention components.

    Conclusions:

    • ApoE polymorphism is associated with alterations in visuospatial attention, even in cognitively healthy individuals.
    • These findings may elucidate early-stage AD pathology and the role of ApoE in cognitive function.
    • Further research into ApoE's molecular mechanisms could improve early AD detection strategies.