Related Experiment Videos
Base-pairing systems related to TNA: alpha-threofuranosyl oligonucleotides containing phosphoramidate linkages
Xiaolin Wu1, Sreenivasulu Guntha, Mathias Ferencic
1The Skaggs Institute for Chemical Biology at the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Organic Letters
|April 13, 2002
Abstract:
(3'NH)- and (2'NH)-TNA, two isomeric phosphoramidate analogues of TNA (alpha-threofuranosyl-(3'-->2') oligonucleotides), are shown to be efficient Watson-Crick base-pairing systems and to undergo intersystem cross-pairing with TNA, RNA, and DNA. [reaction: see text]