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2,6-diaminopurine in TNA: effect on duplex stabilities and on the efficiency of template-controlled ligations
Xiaolin Wu1, Guillermo Delgado, Ramanarayanan Krishnamurthy
1The Skaggs Institute for Chemical Biology at the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Organic Letters
|April 13, 2002
Abstract:
Replacement of adenine by 2,6-diaminopurine-two nucleobases to be considered equivalent from an etiological point of view-strongly enhances the stability of TNA/TNA, TNA/RNA, or TNA/DNA duplexes and efficiently accelerates template-directed ligation of TNA ligands. [reaction: see text]
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