Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Acute lymphoblastic leukemia.

¹Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas., USA.

Current Problems in Pediatric and Adolescent Health Care

|April 16, 2002

Summary

Childhood acute leukemia, a common pediatric cancer, has seen dramatically improved survival rates over 40 years. Advances in treatment strategies for acute lymphoblastic leukemia and acute myelogenous leukemia drive these positive outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Immune Reconstitution and Infection Patterns after Early Alemtuzumab and Reduced Intensity Transplantation for Nonmalignant Disorders in Pediatric Patients.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2018

Same author

Umbilical Cord Blood Transplantation in Children with Acute Leukemia: Impact of Conditioning on Transplantation Outcomes.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2017

Same author

Personalized Prognostic Risk Score for Long-Term Survival for Children with Acute Leukemia after Allogeneic Transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2017

Same author

Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2017

Same author

Response to: "Technology and Long-Term Health-Related Quality-of-Life Outcomes in Children with Nonmalignant Disorders after Reduced-Intensity Conditioning and Stem Cell Transplantation".

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2016

Same author

Long-Term Follow-Up after Reduced-Intensity Conditioning and Stem Cell Transplantation for Childhood Nonmalignant Disorders.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2016

Area of Science:

Pediatric Oncology
Hematology
Cancer Research

Background:

Acute leukemia is the most frequent childhood malignancy in the U.S., accounting for 30% of cancers in children under 15.
Approximately 2500 new cases are diagnosed annually, with acute lymphoblastic leukemia (ALL) comprising 80% and acute myelogenous leukemia (AML) 15%.

Purpose of the Study:

To review the significant improvements in survival rates for childhood acute leukemia.
To highlight the role of therapeutic trial modifications in advancing treatment outcomes.

Main Methods:

Analysis of survival data over the past 40 years.
Review of treatment strategy modifications based on large-scale therapeutic trials.

Main Results:

Dramatic increases in survival rates for children with acute leukemia.
Greatest success observed in acute lymphoblastic leukemia (ALL) treatment.
Recent improvements also reported in acute myelogenous leukemia (AML) outcomes.

Conclusions:

Treatment strategy modifications, informed by sequential trials, are key to improving outcomes.
This approach serves as a model for research in other pediatric malignancies.

Related Experiment Videos