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Liver support systems: a 1978 perspective.

K D Kulbe

    Artificial Organs
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Liver support systems offer short-term solutions using artificial devices like hemodialysis. Long-term liver replacement requires transplantation, while advanced artificial systems aim for detoxification through combined enzyme and adsorbent technologies.

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    Area of Science:

    • Hepatology
    • Biomedical Engineering
    • Artificial Organ Development

    Background:

    • Injured liver function necessitates effective support systems.
    • Current strategies include both short-term artificial interventions and long-term biological replacement.
    • Acute liver failure presents significant challenges in detoxification and functional substitution.

    Purpose of the Study:

    • To review the current status of support systems for injured livers.
    • To differentiate between short-term artificial support and long-term liver replacement options.
    • To explore advanced artificial device concepts for acute liver failure management.

    Main Methods:

    • Literature review of existing liver support systems and devices.
    • Analysis of short-term substitution methods (hemodialysis, hemoperfusion).

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  • Discussion of long-term replacement strategies (liver grafting, transplantation).

    • Main Results:

    • Short-term support primarily utilizes artificial systems like hemodialysis and hemoperfusion with adsorbents.
    • Long-term liver function restoration is currently achievable only through liver transplantation.
    • Sophisticated artificial devices are proposed, integrating immobilized enzymes and adsorptive materials for enhanced detoxification.

    Conclusions:

    • Artificial liver support systems provide crucial short-term assistance.
    • Liver transplantation remains the definitive solution for long-term liver failure.
    • Future artificial devices should combine bioreactors with adsorptive technologies for improved blood detoxification in acute liver failure.