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Bedside testing with the new CoaguChek Pro activated clotting time assay in dialysis
Jürgen Bommer1, Michael Schwab
1Dialysis Center, Heidelberg, Germany.
Abstract:
The objective of this study was to assess the analytical performance of CoaguChek Pro activated clotting time (ACT) assay using 2 lots versus Hemochron Celite and glass ACT regarding ACT values and correlations versus heparin levels. Determinations were performed using 4 CoaguChek Pro meters and 1 Hemochron 801 meter. Samples were collected during hemodialysis before, after start of heparinization, and 2 h later. Agreement between CoaguChek Pro ACT and Hemochron Celite was good (r = 0.82, slope = 1.12) and moderate with Hemochron glass (r = 0.83, slope = 0.97). Agreement between both CoaguChek Pro lots was r = 0.98. Agreement between the activators, Hemochron Celite, and glass was r = 0.73. Correlation between CoaguChek Pro ACT and heparin concentration was r = 0.88 and 0.94; for Hemochron the correlation was r = 0.75 (Celite) and r = 0.73 (glass). CoaguChek Pro ACT is therefore suitable for monitoring heparin administration during dialysis.