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Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
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Published on: August 19, 2016

The cytolethal distending toxin of Haemophilus ducreyi inhibits endothelial cell proliferation

Liselott A Svensson1, Petra Henning, Teresa Lagergård

  • 1Department of Medical Microbiology and Immunology, Göteborg University, S-4136 Göteborg, Sweden.

Infection and Immunity
|April 16, 2002
PubMed

Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, produces a cytolethal distending toxin (HdCDT) that inhibits mammalian cell proliferation. We investigated the effects of HdCDT on normal human endothelial cells and on tubule formation in an in vitro model of angiogenesis. Endothelial cells were arrested in the G2 phase of the cell cycle, and tubule formation was inhibited in a dose-dependent manner. The antiproliferative activities of HdCDT on endothelial cells might contribute to the characteristic slow healing and persistence of chancroid ulcers.

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