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Updated: Aug 19, 2026
Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
[Effect of different estrogen receptor subtypes on vascular endothelial growth factor protein expression in human
Xianfeng Wen1, Zan Shen, Zhimin Shao
1Department of Breast Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China.
Objectives:
To evaluate the relationship of vascular endothelial growth factor expression with estrogen receptor (ER) subtypes in fresh human breast cancer samples, and study the potential effect of ER subtypes on tumor angiogenesis.
Methods:
Western blot was used to detect the VEGF and ERbeta protein expression in 86 fresh samples of human breast cancer. ERalpha was analyzed by immunohistochemistry routinely.
Results:
Among 86 samples, 42 (48.8%) showed low expressed VEGF and 44 (51.2%) high expressed VEGF. The level of VEGF protein was correlated with ERbeta. In high expressed VEGF group, ERbeta was also highly expressed (chi(2) = 7.36, P < 0.01). But there was no significant difference between VEGF protein level and ERalpha (P > 0.05).
Conclusion:
In human breast cancer samples, VEGF may be related to ERbeta protein expression.
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