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Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast
Iain M Cheeseman1, David G Drubin, Georjana Barnes
1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA.
The Journal of Cell Biology
|April 17, 2002
Abstract:
Although the budding yeast centromere is extremely short (125 bp) compared to those of other eukaryotes, the kinetochore that assembles on this DNA displays a rich molecular complexity. Here, we describe recent advances in our understanding of kinetochore function in budding yeast and present a model describing the attachment that is formed between spindle microtubules and centromeric DNA. This analysis may provide general principles for kinetochore function and regulation.