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Is heart failure with preserved systolic function an overlooked enigma?
Mandeep R Mehra1, Patricia A Uber, Srinivasa Potluri
1The Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA. mmehra@ochsner.org
Current Cardiology Reports
|April 19, 2002
Summary
Diastolic heart failure, also known as heart failure with preserved systolic function, significantly impacts morbidity and mortality, especially in the elderly. Early detection and preventive strategies are crucial due to a lack of established evidence-based therapies.
Area of Science:
- Cardiology
- Internal Medicine
- Geriatrics
Background:
- Diastolic heart failure (DHF) is a significant clinical entity, often overlooked, contributing substantially to heart failure morbidity and mortality.
- DHF affects a large patient population, particularly the elderly, and carries a prognosis similar to systolic heart failure.
- Diagnostic criteria for DHF lack standardization, leading to heterogeneity in research and clinical interpretation.
Purpose of the Study:
- To highlight the clinical significance of diastolic heart failure.
- To emphasize the need for standardized diagnostic criteria and early preventive measures.
- To review current therapeutic approaches and ongoing research for DHF.
Main Methods:
- Review of existing literature on diastolic heart failure.
- Analysis of diagnostic challenges and heterogeneity in clinical studies.
- Discussion of current management strategies targeting lusitropic abnormalities.
Main Results:
- Diastolic heart failure is associated with significant morbidity and mortality, comparable to systolic heart failure.
- Lack of standardized diagnostic criteria complicates research and clinical practice.
- No definitive evidence-based therapeutic strategies are established for DHF.
Conclusions:
- Preventive efforts in high-risk groups and screening with novel biomarkers are essential for early intervention.
- Current therapies focus on managing impaired relaxation, diastolic compliance, heart rate, and atrial function.
- Outcomes-based, placebo-controlled trials are ongoing to establish effective therapeutic strategies for DHF.