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Updated: Oct 1, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Sulphonamide residues in eggs following drug administration via the drinking water
1Afssa, Laboratoire des Medicaments Veterinaires, Fougeres, France. b.roudaut@fougeres.afssa.fr
Abstract:
The aim was to determine concentrations of sulphadimidine (SDM) and sulphadimethoxine (SDT) in eggs following oral administration through drinking water for 5 days (0.5 g l(-1) for SDT, 1 and 2 g l(-1) for SDM). Residues of sulphonamides in albumen and yolk were monitored by high-performance liquid chromatography with UV detection. The limit of quantification was 0.005 microg g(-1) for the two egg components. The results indicate that 0.9-1.4% of the dose administered was deposited in eggs. Maximum concentrations in albumen were much higher than those in yolk. More than 75% of the overall sulphonamides detected in eggs was concentrated in the albumen. The residue levels declined below the limit of quantification within 12-20 days for albumen and 14-15 days for yolk after treatment was discontinued.
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