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Imidazole-based ligands of the Src SH2 protein
Pierre Deprez1, Eliane Mandine, Annie Vermond
1Aventis Pharma, Paris Research Center, Medicinal Chemistry, 102 route de Noisy, 93235 Cedex, Romainville, France. pierre.deprez@aventis.com
Bioorganic & Medicinal Chemistry Letters
|April 20, 2002
Abstract:
Starting from known Src SH2 inhibitors incorporating five-membered heterocycles or benzamide scaffolds, we prepared tetrasubstituted imidazole compounds able to interact with the pY, pY+1 and pY+3 binding sites of the Src SH2 protein. The synthesis and biological data are presented.