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Enantiospecific, selective cyclooxygenase-2 inhibitors
Kevin R Kozak1, Jeffery J Prusakiewicz, Scott W Rowlinson
1Department of Biochemistry, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Bioorganic & Medicinal Chemistry Letters
|April 20, 2002
Abstract:
Cyclooxygenase inhibition studies with novel indomethacin alkanolamides demonstrate the potential for dramatic differences in inhibitor properties conferred by subtle structural modifications. The transformation of non-selective alpha-(S)-substituted indomethacin ethanolamides to potent, COX-2 selective inhibitors by simple stereocenter inversion highlights this property.