Related Experiment Videos
Ascending fractional pulse pressure closely relating to large artery function
Y Nakayama1, H Ueda, K Tsumura
1Department of Cardiology, Ishikiriseiki Hospital, Osaka, Japan.
Insights
Ascending fractional pulse pressure (PPf) is closely linked to large artery function, as measured by the augmentation index. This finding suggests PPf is a valuable indicator of arterial health in older adults.
Area of Science:
- Cardiovascular Physiology
- Arterial Hemodynamics
- Biomedical Engineering
Background:
- The relationship between ascending fractional pulse pressure (PPf) and large artery function remains unclear.
- Large artery stiffness is a significant predictor of cardiovascular events.
- Augmentation index is a validated measure of large artery function.
Purpose of the Study:
- To investigate the association between ascending fractional pulse pressure (PPf) and large artery function.
- To determine if PPf can serve as a biomarker for arterial stiffness.
Main Methods:
- Ascending aortic pressure was measured in 190 subjects (age 50-78) using a fluid-filled system.
- Fractional pulse pressure (PPf) was calculated by normalizing pulse pressure to mean pressure.
- The association between PPf and augmentation index was analyzed using univariate and multivariate regression.
Main Results:
- A significant positive association was found between PPf and augmentation index (R = 0.690, P < 0.001).
- Multivariate analysis revealed PPf is significantly associated with age, mean aortic pressure, heart rate, and type 2 diabetes (R(2) = 0.477, P < 0.001).
Conclusions:
- Ascending aortic fractional pulse pressure (PPf) is closely associated with large artery function.
- PPf may be a useful non-invasive indicator of arterial stiffness and cardiovascular risk.
Abstract:
It is not known whether ascending fractional pulse pressure (PPf) is related to large artery function. This study was to evaluate whether PPf is associated with large artery function by augmentation index. A total of 190 subjects were enrolled (age range: 50 to 78 years) who had normal contractions, no local asynergy, and no history of myocardial infarction. The ascending aortic pressure was measured using a fluid-filled system. To quantify the relative magnitude of the pulsatile to mean artery pressure, we normalised the pulse pressure to the mean pressure and referred to this value as PPf and the association between the PPf and the augmentation index was investigated. Augmentation index showed significant associations with PPf by univariate analysis (R = 0.690, P < 0.001). The associations between PPf and the factors influencing large artery function were examined by multivariate analysis, and PPf revealed significant associations with age, mean aortic pressure, heart rate and type 2 diabetes (R(2) = 0.477, P < 0.001). The results were that ascending aortic PPf is closely associated with large artery function detected by augmentation index.