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Neurogenic appendicopathy in children.

C Franke1, C-D Gerharz, H Böhner

  • 1Department of General and Trauma Surgery, Heinrich-Heine-University, Düsseldorf, Germany. Claus.Franke@med.uni-duesseldorf.de

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [Et Al] = Zeitschrift Fur Kinderchirurgie
|April 23, 2002
PubMed
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Neurogenic appendicopathy (NA) is rare in children, affecting 4.8% of those studied. Clinical presentation does not reliably distinguish NA from acute appendicitis, even in negative appendectomy cases.

Area of Science:

  • Histopathology
  • Surgical Pathology
  • Pediatric Surgery

Background:

  • Neurogenic appendicopathy (NA) is a recognized histological entity.
  • Previous studies established NA as a distinct histopathological finding.
  • This study investigates NA's clinical presentation and incidence across pediatric and general populations.

Purpose of the Study:

  • To compare the clinical presentation and incidence of neurogenic appendicopathy (NA) between pediatric and adult populations.
  • To determine the frequency of NA in children versus adolescents and adults undergoing appendectomy.
  • To assess the feasibility of preoperative differentiation between NA and acute appendicitis.

Main Methods:

  • Prospective multicenter study including patients undergoing appendectomy for suspected appendicitis.

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  • Exclusion criteria: patients younger than 6 years and those with incomplete data.
  • Diagnosis of NA confirmed via S-100 immunochemistry and/or H.E. staining; comparison of NA frequency in age groups (< or = 14 years vs. > 14 years).

    • Main Results:

    • NA was found in 4.8% of pediatric cases (4/84) versus 24.2% in adolescents and adults (48/198).
    • In patients with negative appendectomies, NA prevalence was 16.7% in children and 56.6% in adults.
    • Clinical differentiation between NA and acute appendicitis was not possible due to small sample sizes.

    Conclusions:

    • Neurogenic appendicopathy is a rare histopathological entity in the pediatric population.
    • Preoperative differentiation between acute appendicitis and neurogenic appendicopathy based on clinical presentation and history is not feasible.