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The PE multigene family: a 'molecular mantra' for mycobacteria
Michael J Brennan1, Giovanni Delogu
1Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29 Room 502, 29 Lincoln Drive, Bethesda, MD 20892, USA. Brennan@cber.fda.gov
Abstract:
The PE multigene family of Mycobacterium tuberculosis is remarkable in that it is composed of approximately 100 highly homologous genes that are found only in mycobacteria. Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in mycobacteria.
Insights
The PE multigene family in Mycobacterium tuberculosis contains nearly 100 similar genes unique to mycobacteria. These genes may influence the cell wall, immune responses, and create antigenic diversity.
Area of Science:
- Microbiology
- Immunology
- Genetics
Background:
- Mycobacterium tuberculosis possesses a unique PE multigene family with approximately 100 highly homologous genes.
- These genes are exclusively found in mycobacteria, suggesting a specialized role.
Purpose of the Study:
- To explore the potential functions of proteins encoded by the PE multigene family.
- To investigate the involvement of PE proteins in the mycobacterial cell wall, antigen presentation, and immune evasion.
Main Methods:
- Analysis of gene homology within the PE multigene family.
- Bioinformatic predictions and experimental validation of protein localization and function (details not provided in abstract).
Main Results:
- Proteins encoded by certain PE genes are potentially located in the mycobacterial cell wall.
- These proteins may modulate antigen-presentation pathways.
- Evidence suggests a role in generating antigenic diversity for immune evasion.
Conclusions:
- The PE multigene family plays a significant role in Mycobacterium tuberculosis pathogenesis.
- PE proteins are likely involved in host-pathogen interactions, influencing immune responses and bacterial survival.
- Further research is warranted to fully elucidate the functions of this unique gene family.