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[Intrauterine growth retardation, its consequences in infancy, in the child and long term]
B L Salle1, P Chatelain, M Nicolino
1Service de Néonatalogie et Réanimation néonatale, Hôpital Edouard Herriot, 69437 Lyon.
Insights
Intrauterine growth restriction can lead to growth hormone treatment in infancy. Adults born with low birth weight face an 18x higher risk of developing metabolic syndrome.
Area of Science:
- Pediatric Endocrinology
- Developmental Biology
- Public Health
Context:
- Intrauterine growth restriction (IUGR) affects 7-10% of infants, often requiring intervention.
- Low birth weight (<2.4 kg) is a significant risk factor for later-life health issues.
- Understanding the long-term consequences of IUGR is crucial for preventative healthcare.
Purpose:
- To investigate the long-term health outcomes of infants experiencing intrauterine growth restriction.
- To quantify the increased risk of adult diseases associated with low birth weight.
- To provide recommendations for the follow-up care of infants with growth restriction.
Summary:
- Infants with severe growth restriction (<-2 DS) may require growth hormone therapy.
- Adults born with low birth weight exhibit an 18-fold increased incidence of metabolic syndrome (hypertension, type 2 diabetes, cardiovascular disease).
- The study highlights the critical link between early-life growth and adult disease prevalence.
Impact:
- Informs clinical guidelines for managing IUGR and its long-term health implications.
- Emphasizes the importance of monitoring and early intervention for at-risk infants.
- Contributes to public health strategies aimed at reducing the burden of non-communicable diseases.
Abstract:
The authors report the consequence of intra-uterine growth retardation on infancy and adult disease. During infancy in 7 to 10% of cases a growth retardation less than -2 DS, is observed and subsequently needs growth hormone treatment. In adult X syndrome (hypertension, diabetes of 2 types insulino resistant and cardiovascular disease) is observed 18 times more in subjects where the birth weight was low than 2.4 kg. Finally the authors give some recommendations to follow-up of the infants born with a growth restriction.