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A new atropisomeric P,N ligand for rhodium-catalyzed asymmetric hydroboration

Fuk Yee Kwong1, Qingchuan Yang, Thomas C W Mak

  • 1Department of Chemistry, Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

The Journal of Organic Chemistry
|April 27, 2002
PubMed

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One of the convenient methods for the preparation of aldehydes and ketones is via hydration of alkynes. Hydroboration-oxidation of alkynes is an indirect hydration reaction in which an alkyne is treated with borane followed by oxidation with alkaline peroxide to form an enol that rapidly converts into an aldehyde or a ketone. Terminal alkynes form aldehydes, whereas internal alkynes give ketones as the final product.
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