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Acid-catalyzed formation of hexahomooxacalix[3]arenes
Mijan Miah1, Nikolai N Romanov, Peter J Cragg
1School of Pharmacy and Biomolecular Science, University of Brighton, Brighton BN2 4GJ, UK.
The Journal of Organic Chemistry
|April 27, 2002
Abstract:
The role of acid catalysis in oxacalix[3]arene synthesis has been investigated. A range of acids were used to optimize the yield of tert-butyloxacalix[3]arene, the most efficient being p-toluenesulfonic acid, which, with local symmetry complementary with that of the lower rim of the calixarene, provides a templating effect.