Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Designer skin: lineage commitment in postnatal epidermis.

Catherin Niemann1, Fiona M Watt

  • 1Keratinocyte Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, WC2A 3PX., London, UK.

Trends in Cell Biology
|April 30, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

At the helm of JCS - Editors-in-Chief past, present… and future.

Journal of cell science·2025
Same author

Specific and redundant roles for Gli2 and Gli3 in establishing cell fate during murine hair follicle development.

The EMBO journal·2025
Same author

Cell volume regulates terminal differentiation of cultured human epidermal keratinocytes.

Journal of cell science·2025
Same author

Controlled anarchy.

EMBO reports·2025
Same author

Fetal Fibroblast Heterogeneity Defines Dermal Architecture during Human Embryonic Skin Development.

The Journal of investigative dermatology·2025
Same author

Corrigendum to 'Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility' Journal of Investigative Dermatology, Volume 136, Issue 1, January 2016, Pages 99-106.

The Journal of investigative dermatology·2025

Epidermal stem cells generate diverse skin cell types. Their microenvironment influences differentiation, and postnatal epidermis can be reprogrammed to alter cell lineage patterns.

Area of Science:

  • Dermatology and Stem Cell Biology
  • Investigating the cellular dynamics and developmental plasticity of the skin epidermis.

Background:

  • The epidermis contains stem cells responsible for generating differentiated cells for skin, hair, and glands.
  • Stem cell fate is heavily influenced by their microenvironment, including signaling molecules, cell interactions, and the extracellular matrix.

Purpose of the Study:

  • To review current knowledge on epidermal stem cell populations and their lineage relationships.
  • To present evidence for the reprogramming potential of postnatal epidermis.

Main Methods:

  • Literature review on epidermal stem cell biology.
  • Analysis of experimental data demonstrating postnatal epidermal reprogramming.

Main Results:

Related Experiment Videos

  • Established stem cell populations and lineage pathways within the epidermis are summarized.
  • Evidence is presented showing that the postnatal epidermis can be altered to change cell differentiation patterns.

Conclusions:

  • The microenvironment plays a critical role in directing epidermal stem cell differentiation.
  • Postnatal epidermal cells exhibit plasticity, allowing for reprogramming of differentiation pathways.