[Autonomic system disorders in endemic goiter].

Area of Science:

• Endocrinology
• Autonomic Nervous System Research
• Clinical Medicine

Context:

• Endemic goiter (EG) affects autonomic nervous system function.
• Vegetative dystonia syndrome (VDS) is a common comorbidity in EG patients.
• Understanding VDS in EG is crucial for effective patient management.

Purpose:

• To investigate vegetative tonicity, reactivity, and provision in EG patients.
• To characterize the nature of VDS in the context of EG.
• To evaluate the impact of VDS on patient performance and disease reaction.

Summary:

• Vegetative dystonia syndrome (VDS) in endemic goiter (EG) patients presents as parasympathicotonia.
• Subjective symptoms of vegetative dysregulation correlate with anxiety and neuroticism, not introversion/extraversion.
• VDS in EG impairs mental and physical performance, attention, and disease response; vegetative reactivity becomes hypersympathicotonic.

Impact:

• Findings suggest heart valve prolapse in EG is more likely due to myocardial edema than VDS, questioning beta-blocker efficacy.
• Replacement hormone therapy with thyroxine demonstrates a gradual attenuation of vegetative dysregulation in EG patients.
• This research informs treatment strategies for EG, emphasizing hormone replacement over certain autonomic interventions.